నైరూప్య

A Shot Note on Thermodynamics of RNA

Shaheed Shettipally

Reliable prediction of RNA?RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA?mRNA binding and antisense interactions. The thermodynamics of such RNA?RNA interactions can be understood as the sum of two energy contributions: (1) the energy necessary to ?open? the binding site and (2) the energy gained from hybridization.