నైరూప్య

Association of IL-8 genetic polymorphisms and breast cancer risk in a Chinese population

Yinzai He, Shengrong Sun, Yanheng Liu, Kun Tian

Breast cancer is the most common cancer among women worldwide. The development of breast cancer is a multistep process. IL-8 belongs to the superfamily of CXC chemokines, and it could promote the growth of tumors by elevating angiogenesis. We aimed to investigate the association risk of IL-8 -251T/A (rs4073), +781C/T (rs2227306) and +396T/G (rs2227307) polymorphisms with breast cancer in a Chinese population. A total of 411 breast cancer patients and 411 control subjects were recruited in this study. Genotyping of IL-8-251T/A (rs4073), +781C/T (rs2227306) and +396T/G (rs2227307) was carried out in a 384-well plate format on the sequenom MassARRAY platform. Information on demographic, lifestyle and clinical characteristics were collected from medical records and questionnaire interviews. After adjusting for the environmental factors, we observed that the AA genotype of IL-8 -251T/A (rs4073) was associated with an increased risk of breast cancer in comparison to the TT genotype (OR=2.36, 95% CI=1.29-4.32). No association was observed between IL-8 +781C/T (rs2227306) and +396T/G (rs2227307) and risk of breast cancer. This study suggests that the IL-8 polymorphisms contribute to the risk of breast cancer in a Chinese population.