నైరూప్య
Behavior of QT interval in HIV-Infected Patients Receiving Antiretroviral Therapy
Ana Margarita Jerez Castro 1â?, Ana Danissa Michel Vásquez 2, Edgar Samael Reyes Martinez 3, Mahmoud M. Kamel1, Mohamed A. Betiha4 and Hassan M.A. Hassan1 1,2,3 Resident of Cardiology in the Institute National of Cardiology in Cuba
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Human immunodeficiency virus infections have been associated with arrhythmias, in which antiretroviral drugs play a major etiological role. Objective: to describe the behavior of the QT interval and its dispersion among patients with positive human immunodeficiency virus under antiretroviral treatment. Methods: a descriptive, longitudinal and prospective study was carried out in 1139 patients with human immunodeficiency virus. The demographic variables (sex, age), epidemiological (cardiovascular risk factors), immunological (viral load, CD4 + count) and electrocardiographic variables (corrected QT, QT dispersion, ventricular arrhythmias) were analyzed. Results: male sex, tobacco and opportunistic infections were the most prevalent. The immunological variables responded adequately to the antiretroviral. There was a non-pathological increase in QT interval and QT dispersion, especially when lopinavir was used. Ventricular arrhythmias were reported in 23.6% and sudden death in 10%. Conclusions: prolongation and dispersion of the QT interval, ventricular arrhythmias and sudden death were associated with HIV infection that was short-lived and associated with protease inhibitors.
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