నైరూప్య

Diabetes insulin resistance reversal

Dibyajyoti Saikia

Hypoglycemia, produced by insulin, a sulfonylurea, or glided therapy, combined with weakened defences against dropping plasma glucose concentrations, is the limiting factor in diabetes glycaemic management. It causes recurrent morbidity in the majority of persons with type 1 diabetes and many people with advanced type 2 diabetes, and it can be fatal in some cases. The compromised defences are loss of a decrease in insulin and loss of an increase in glucagon and attenuation of an increase in epinephrine as glucose levels fall, resulting in defective glucose counter-regulation and impaired awareness of hypoglycaemia due to an attenuated sympathoadrenal response, possibly caused by recent antecedent hypoglycaemia, prior exercise, or sleep, among other mechanisms.