నైరూప్య

Menetrier’s disease without Helicobacter pylori mimicking gastric linitis plastica-A rare entity which mimicks gastric cancer.

Duminda Subasinghe1*, Ranjanie Selvakumar2, Thambawita Gurunnanselage Amal Priyantha1

Menetrier’s disease is a rare premalignant hypertrophic gastropathy. It is characterized by upper gastrointestinal symptoms such as epigastric pain, discomfort, nausea, vomiting, peripheral oedema and hypertrophied gastric mucosal folds on endoscopy. An 80-year-old female presented with the complaints of severe epigastric pain, anorexia, vomiting, nausea and vomiting for 3 months. Upper gastrointestinal endoscopy and CT scan revealed thickening of gastric mucosa. Endoscopic biopsy showed gastric foveolar hyperplasia and glandular atrophy which are diagnostic for Menetrier’s disease. There was no evidence of Helicobacter pylori infection. Her laboratory investigations revealed hypoalbuminemia and anemia. She was symptomatically managed as she did not opt for any surgical intervention. Menetrier’s disease should be suspected in patients with upper gastrointestinal symptoms, hypoalbuminemia and hypertrophied gastric mucosa even without Helicobacter pylori infection. Preoperative diagnosis could not be confirmed unless adequate deep gastric biopsy is performed