నైరూప్య

More than just another fungal virulence factor

Holly P. Bartholomew

Mycotoxin contamination is a leading cause of food spoilage around the world. Among one of the top mycotoxins of global concern is patulin, which is found in processed apple products (e.g. juice, sauce, and butter). Produced mainly by Penicillium and Aspergillus species, patulin is a lactone polyketide that has cytotoxic effects in humans, survives pasteurization, and is not destroyed following fermentation. While much has been discovered regarding the impact of patulin on human health, there are significant knowledge gaps for how it impacts the host and other fungi. Here, we have utilized purified patulin to determine if the toxin could mimic blue mold symptoms. Directly inoculating apple fruit with different amounts of patulin revealed a cultivar-independent susceptibility, as well as a dose response where blue mold symptoms and toxin concentration coincided. Patulin biosynthesis was recently discovered to be produced outside of the fungal cell, so understanding how it impacts other phytopathogenic fungi was investigated