నైరూప్య

Renal survival analysis of CAKUT and outcomes in chronic kidney disease

Oke Rina Ramayani, Kiking Ritarwan, Putri Chairani Eyanoer, Rosmayanti Siregar, Rafita Ramayati

Background: The prevalence of ESRD has risen rapidly worldwide due to congenital anomalies of the kidney and urinary tract (CAKUT). In the developing countries, these abnormalities could be delay in diagnosed, and treatment. The aim of this study was to analyzed renal survival patients of CAKUT and outcomes in chronic kidney disease. Methods: In this cohort study, 53 CAKUT patients were followed up. Clinical end points were censored on 31st September, 2017. ESRD or death was assigned as a dependent variable. Renal survival was measured from the date of patient chronological ages to the date of initiation of renal dialysis or to the date of ?rst eGFR <15 ml/min per 1.73 m2 (stage 5) or death secondary to renal causes. Results: The frequency of renal diagnosis based on CAKUT abnormalities are 38 in obstructive type and 15 in non obstructive type. Mean age for obstructive type was 8.9 ± 4.42 years and for non obstructive type 9.92 ± 2.42 years. Mean basal glomerular filtration rate was 52.8 ml/min/1.73 m2 for obstructive type and 55.4 ml/min/1.73 m2 for non obstructive type. Median follow-up of all CAKUT patients was 15 years (14.54-15.46 years). The median renal survival for obstructive type was 14.50 (8.09-20.90) years and for non-obstructive type 15.00 (6.92-23.07). There was no significant difference them. Conclusion: The understanding management of CAKUT makes it possible for children with CAKUT to have fewer complications, have longer renal survival, and survive even with ESRD through renal replacement therapy.