నైరూప్య

Detecting Prodigiosin molecular mechanism pathway in Breast Cancer through an integrated systems biology approach

Shaimaa Ahmed Abdel-mougood

 Prodigiosin the red pigment extracted from Serratia marc¬esens and other species, was known as the miracles of bloody bread in the medieval age. it is a “prodigious” com¬pound with high medical and industrial significance. it has antibacterial, antiprotozoal, algicidal, antimalarial, antican¬cer, and immunosuppressive properties it also used indus¬trially as a pigment. Breast cancer (BC) is a heterogeneous disease that considered the most common malignancy in women in several countries. It is classified into several sub-types, each one involving a different gene set controlling for diverse processes. The identification of cancer sub-type depends on the expression of the estrogen receptor (ER), progesterone receptor (PR), cytokeratin (CK) protein and epi¬dermal growth factor receptor 2 (ERBB2). Previous studies have shown that prodigiosin induced significant apoptosis in a broad range of cancer cell lines selectively and effectively target cancer but not healthy cells. Importantly, it is less toxic than other anticancer drugs and its pro-apoptotic effect irre¬spective of p53 status and multidrug resistance, rendering prodigiosin a promising anticancer drug. Through Integrat¬ed Systems Biology tools the aim of this study is to explore possible molecular mechanism pathway of prodigiosin and detect gene signature involved in its therapeutic response.